Naproxen

Lore & Background

Naproxen is a nonselective COX inhibitor that reduces the production of inflammatory mediators called prostaglandins. It is metabolized by the liver to inactive metabolites. Common side effects include dizziness, headache, bruising, allergic reactions, heartburn, and stomach pain. Severe side effects include increased risk of heart disease, stroke, gastrointestinal bleeding, and stomach ulcers, though the heart disease risk may be lower than with other NSAIDs. It is not recommended in people with kidney problems or during the third trimester of pregnancy. Naproxen is also used as a 'bridge therapy' in medication-overuse headache to slowly take patients off other medications.

Reader's Guide

Naproxen's significance lies in its widespread use as an effective analgesic and anti-inflammatory agent, available both over-the-counter and by prescription. Its long duration of action (up to twelve hours) and availability in immediate and extended-release formulations make it versatile for acute and chronic conditions. However, its use requires caution due to gastrointestinal and cardiovascular risks, though it is associated with the smallest overall cardiovascular risks among NSAIDs. The drug's inclusion on the WHO List of Essential Medicines underscores its global therapeutic importance. Naproxen's legacy is as a reliable, well-studied NSAID that balances efficacy with a manageable risk profile when used appropriately.

Did You Know?

• It is available in both immediate and delayed release formulations, with onset of effects within an hour lasting up to twelve hours.
• Naproxen is a nonselective COX inhibitor that reduces production of prostaglandins.